A research team led by Prof. ZHU Shu from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS) illustrated the role of Gasdermin D (GSDMD) protein in immunity tolerance to food in the small intestine. The study was published in Cell. GSDMD, an executioner protein of cell pyroptosis, has garnered widespread attention. When cells are stimulated by pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs), the signaling receptors within the cells activate caspase-1/4/5/8/11, leading to the N-terminal cleavage of GSDMD and the generation of the p30 fragment, which triggers cell pyroptosis and…