In a recent article published in the journal Nature, researchers used a classical concept in computational linguistics to design a new algorithm, LinearDesign, which optimized the structural stability and codon usage of messenger ribonucleic acid (mRNA) sequences. For instance, using this algorithm, researchers could optimize mRNA sequences encoding the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein and use it in mRNA-based coronavirus disease 2019 (COVID-19) vaccines. Study: Algorithm for Optimized mRNA Design Improves Stability and Immunogenicity. Image Credit: metamorworks / Shutterstock Background All vaccines based on the relatively new mRNA technology suffer from common limitations, such as...