Background: Premature ejaculation (PE) is one of the most described psychosocial stress and sexual complaints worldwide. Previous investigations have focused predominantly on the prospective identification of cases that meet researchers’ specific criteria. The genuine demand from patients with regard to information on PE and related issues may thus be neglected. Objective: This study aims to examine the online search trend and user demand related to PE on a national and regional scale using the dominant major search engine in mainland China. Methods: The Baidu Index was queried using the PE-related terms for the period of January 2011 to December 2020....